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Saturday, July 18, 2020 | History

4 edition of Molecular mechanisms of adult stem cell aging found in the catalog.

Molecular mechanisms of adult stem cell aging

by Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging (1st 2009 Günzburg, Germany)

  • 389 Want to read
  • 29 Currently reading

Published by Karger in Basel .
Written in English

    Subjects:
  • Stem cells -- Congresses,
  • Cells -- Aging -- Congresses,
  • Aging -- Molecular aspects -- Congresses,
  • Adult Stem Cells -- physiology -- Congresses,
  • Cell Aging -- genetics -- Congresses,
  • DNA Damage -- physiology -- Congresses,
  • Telomere -- genetics -- Congresses

  • Edition Notes

    Includes bibliographical references and index.

    Statementvolume editor, Karl Lenhard Rudolph.
    GenreCongresses
    SeriesElse Kröner-Fresenius symposia -- v. 1, Else Kröner-Fresenius symposia -- v. 1.
    ContributionsRudolph, K. Lenhard.
    Classifications
    LC ClassificationsQH588.S83 E447 2009
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL24110342M
    ISBN 109783805592437
    LC Control Number2010007472

      Molecular Mechanisms of Nutrient Programming in Skeletal Muscle Epigenetic Regulation of Skeletal Muscle Nutrient Programming 3. Epigenetics of Aging in Skeletal Muscle Stem Cell Proliferation, Differentiation, Regeneration and Self-renewal Role of Satellite Cells in Aging Skeletal Muscle Repair and Regeneration The Future of Anti-Aging & Stem Cell Therapy. Recent research discoveries have uncovered the molecular mechanisms of aging, specifically signaling pathways. These signaling pathways are involved in the interactions between allograft stem cells and their environment referred to as the “stem cell niche”. Book an Appointment with Stem.

      For example, the cellular and molecular mechanisms leading to mature and adult cells developmental abnormalities are relatively unknown. This lack of understanding stems from the lack of a good model system to study cell development and differentiation. David Tosh, Marko E. Horb, in Handbook of Stem Cells (Second Edition), 1 Identify Potential Factors to Induce Transdifferentiation. Transdifferentiation may be achieved in several ways using extracellular growth factors, individual transcription factors, or combinations of the two. An understanding of how individual organs or cell types form will help to identify those molecular factors.

    Exhaustion of adult stem cell pools as a result of deranged Though molecular mechanisms A further complication in teasing apart the effects of aging on adult stem cell compartments is the changing interaction between stem cell types and with an aging immune system (reviewed in [39]). However, a comprehensive understanding of the molecular mechanisms underlying aging has been hampered by its complex nature. Although the process has been subjected to substantial data-driven stem cell aging, although many other risk factors contri- verse the decline of adult stem cells (Mair et al. ). Moreover, CR enhances brain.


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Molecular mechanisms of adult stem cell aging by Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging (1st 2009 Günzburg, Germany) Download PDF EPUB FB2

Understanding the molecular and cellular mechanisms involved Molecular mechanisms of adult stem cell aging book critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms.

Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

This book provides a thorough, yet brief, review of cell aging through discussions of various mechanisms of aging and age-related diseases and would be useful for a graduate student symposium or newcomers to the field of cell aging.” (Ellen Mary Andrews, Doody’s Book Reviews, April, )Cited by: 3.

Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as well as attempting to define the.

Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging: a meeting report and introduction to the field / Rudolph, K.L. --Speakers at the Symposium / Hartmann, D.

--Hematopoietic stem cell aging and fate decision / Illing, A., Ju, Z. --Alterations of systemic environment impair stem cell function during aging / Song, Z., Ju, Z. --Novel insights into regulation of stem cell.

This is a good introduction to the field of cell aging. This book provides a thorough, yet brief, review of cell aging through discussions of various mechanisms of aging and age-related diseases and would be useful for a graduate student symposium or newcomers to the field of cell aging.” (Ellen Mary Andrews, Doody’s Book Reviews, April.

The molecular mechanisms involved in the aging of stem cells are. the same as the ones involved in the aging of somatic cells, including telomere shorten. ing, oxidative stress, epigenetic.

Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity.

The mechanisms leading to age-dependent decline in stem cell function and potential therapeutic avenues for reversal of these effects are discussed. Aging tissues experience a. As stem cells are among the longest-living cells within an organism, stem cell aging is highly relevant as a driver of organismal aging, health and longevity.

Although phenotypes and mechanisms vary widely, all stem cell populations, it appears, decline in function with age. Stem cell aging: mechanisms, regulators and therapeutic opportunities and perhaps other adult stem cells Low levels of ROS are required for quiescence and stem cell maintenance, Evidence suggests that a similar approach might be applied to reset the molecular memory of aging cells.

We will discuss here the integrative studies of the stem cell aging and a therapeutic effect of adult stem cells including the umbilical cord blood and the underlying mechanisms of the complex process at diverse molecular levels, with the final goal of practically applying stem cell treatment to the aged for maintaining health over by: 1.

The monograph begins with a section that examine the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up.

Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at.

The molecular mechanisms associated with deficits in organ stem cell function with advancing age are for the most part unknown. Nonetheless, recent studies are beginning to shed light on the processes involved in stem cell aging, particularly in adult skeletal muscle stem cells, namely satellite cells.

Studies on the molecular causes/effects of aging in adult stem cells have shown that in aged subjects these cells display an altered proteome, with proteins involved in cytoskeletal organization and anti-oxidant defense being age-dependent and associated with functional impairment of the cell, including decreased responsiveness to physical environmental cues and decreased resistance to oxidative stress.

This perspective is integrated into each chapter of "Molecular and Cellular Biology of Aging." Comparative aspects of aging are emphasized throughout the book and, where possible, those molecular and cellular mechanisms are delineated, highlighting those that are unique to a particular species or animal group.

Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of tissue-specific stem cells and that the epigenetic marks are altered in stem cells during physiological aging. Intriguingly, aging-associated stem cell functional decline can be reversed by manipulating epigenetic factors that become dysregulated during aging.

Los Angeles, CA, USA – Scientists from the USC Stem Cell laboratories of Neil Segil and Justin Ichida are whispering the secrets of a simpler way to generate the sensory cells of the inner ear.

Their approach uses direct reprogramming to produce sensory cells known as “hair cells,” due to their hair-like protrusions that sense sound waves. Advances in medical science and technology allow people live longer lives, which results in age-related problems.

Humans cannot avoid the various aged-related alterations of aging; in other words, humans cannot remain young at molecular and cellular levels. InHarman proposed the “free radical theory of aging” to explain the molecular mechanisms of aging.

[Show full abstract] Else Kröner-Fresenius Symposium on the Molecular Mechanisms of Adult Stem Cell Aging indicating that molecular alterations in intestinal stem cells occur during aging and can.

Premature ageing diseases are powerful models to study the cellular and molecular causes and mechanisms of physiological ageing and AADs. hallmarks of aging. Cell dependent adult stem cell.One of these causes is the aging of stem cells. The biological function of stem cells is the replacement of cells that are lost due to illness, injury or normal fluctuations in the maintenance of tissue homeostasis.

Molecular mechanisms involved in stem cell aging are similar to those involved in the aging of somatic cells.